Role for IL-1 Family Cytokines in Fungal Infections

Autophagy and IL-1 Family Cytokines

Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses...

Fungal infections of the CNS - Section 1

While fungal infections of the CNS are relatively rare, they have become more common with the increasing number of individuals who are immunocompromised due to HIV/AIDS, immunosuppressive therapies, invasive diagnosis and treatment methods, and organ transplants. CNS fungal infections present many diagnostic and therapeutic challenges and are associated with a high mortality rate. Cryptococcal ...

IL-1 family cytokines trigger sterile inflammatory disease

Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about ...

Fungal infections of the Respiratory Tract-Section 1

Fungal infections of the Respiratory Tract are important causes of morbidity and mortality in immunocompromised hospitalized patients. Among these patients are those receiving cytotoxic chemotherapy for neoplastic diseases, those undergoing bone marrow stem cell transplantation or organ transplantation, and those affected with the acquired immune deficiency syndrome. Invasive Aspergillosis has ...

Regulation of IL-1 Family Cytokines IL-1 , IL-1 Receptor Antagonist, and IL-18 by 1,25-Dihydroxyvitamin D3 in Primary Keratinocytes